巻号一覧
76 巻, 3 号
選択された号の論文の38件中1～38を表示しています
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荒川 宗三郎, 石田 三郎, 河口 太郎1956 年 76 巻 3 号 p. 227-230
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーSolubilities of the systems acetanilide-water-acetic acid, phenacetin-water-acetic acid, and p-acetanisidine-water-acetic acid were measured at 10°, 30°, and 50°. In general, the solubility of acetamino compounds tended to increase with the increasing concentration of acetic acid and higher the temperature. The solubility of acetamino compounds at various temperatures, i.e. the saturation curve, reached the maximum at around 5% concentration of water and the solubility tended to decrease with the decreasing amount of water. The solubility of acetamino compounds was also found to decrease with the increase of their molecular weight.抄録全体を表示PDF形式でダウンロード (549K) -
Pyrimidine誘導体の合成研究その1 Pyrimidine誘導体のMannich反応 (i)平野 弘, 米本 春生1956 年 76 巻 3 号 p. 230-233
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリー2-Methyl-4-amino-6-hydroxypyrimidine (I) submits to the Mannich reaction in acid medium with formaldehyde and piperidine, dimethylamine, or dethylamine and forms 5-piperidinomethyl (IIa), 5-dimethylaminomethyl (IIb), or 5-diethyl-aminomethyl (IIc) compound. (I) also submits to the Mannich reaction even with formaldehyde and methylamine to form the 5-methylaminomethyl derivative (IId) though the yield is poor compared to the use of secondary amines. 2-Methyl-4, 6-dihydroxypyrimidine (VI) also forms the 5-piperidinomethyl derivative (VII) by reaction with formaldehyde and piperidine but the yield is also poor in this case. 2-Methyl-4-amino-5-aminomethylpyrimidine (VIII) was obtained by heating the methiodide of 2-methyl-4-amino-5-dimethylaminomethylpyrimidine (Vb), derived from (IIb), in conc. ammonia water.抄録全体を表示PDF形式でダウンロード (664K) -
Pyrimidine誘導体の合成研究 その2 Pyrimidine誘導体のMannich反応 (ii)平野 弘, 米本 春生1956 年 76 巻 3 号 p. 234-239
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリー2-Methyl-4-amino-6-hydroxypyrimidine (I) undergoes Mannich reaction with formaldehyde and piperidine, even in aqueous alkali solution and forms 2-methyl-4-amino-5-piperidinomethyl-6-hydroxypyrimidine (II), but the use of an excess of formaldehyde and piperidine results in the formation of the bis (piperidinomethyl) compound (III) of (I). Examination of the chemical properties and ultraviolet absorption spectrum of the bis compound (III) indicated the compound to be 2-methyl-4-piperidinomethylamino-5-piperidinomethyl-1, 6-dihydropyrimid-6-one (IIIf) and, at the same time, (I) and (II) were assumed to be the 1, 6-dihydropyrimid-6-one compounds (Ia) and (II′). 2-Methyl-4-methylamino-1, 6-dihydropyrimid-6-one (VII), similar to the 4-amino compound (Ia), also undergoes Mannich reaction with formaldehyde and piperidine to form 2-methyl-4-methylamino-5-piperidinomethyl-1, 6-dihydropyrimid-6-one (VIII).抄録全体を表示PDF形式でダウンロード (927K) -
Pyrimidine誘導体の合成研究 その3 Pyrimidine誘導体の赤外線吸収スペクトル平野 弘, 米本 春生, 神尾 英雄1956 年 76 巻 3 号 p. 239-245
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーInfrared absorption spectral analyses of the pyrimidine derivatives reported in the preceding paper revealed the following facts. The 4-aminopyrimidine derivatives without a piperidinomethyl group in the 5-position shows a normal absorption of the primary amine in a carbon tetrachloride solution, while the absorption of the primary amine of the 4-amino group in the 4-amino-5-piperi-dinomethyl derivative, in carbon tetrachloride solution, shifts to a longer wave length region by the intramolecular hydrogen bonding. The absorption spectrum has endorsed the structure of the bis (piperidinomethyl) compound of 2-methyl-4-amino-6-hydroxypyrimidine, which had been assumed as 2-methyl-4-piperidino-methylamino-5-piperidinomethyl-6-hydroxypyrimidine. The absorption band of OH at 3000-2700cm-1 in 6-hydroxypyrimidine derivatives was observed at 2200-2100cm-1 by deuterium substitution from which it was assumed that the compound is present as a dimer, indicated in Fig. 5 (a).抄録全体を表示PDF形式でダウンロード (934K) -
ヤブソテツ属のフラボノイド その1 フラボノイドアグリコンについて岸本 安生1956 年 76 巻 3 号 p. 246-249
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーThe crude flavonoid glycosides obtained from Cyrtomium falcatum Presl and C. Fortunei J. Sm., and its variety, var, clivicola Tagawa, were hydrolysed, respectively yielding two new flavanones, cyrtominetin (I) and cyrtopterinetin (II), besides kaempferol and quercetin. The analytical values of (I) agree with the formula C17H16O6 and (I) forms a tetraacetate, while (II) gives a triacetate and its analytical values agree with C17H16O5. (I), (II), and their acetates show weak optical rotatory power and do not possess any methoxyl group.抄録全体を表示PDF形式でダウンロード (533K) -
ヤブソテツ属のフラボノイド その2 フラボノイイド配糖体について岸本 安生1956 年 76 巻 3 号 p. 250-253
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーFlavonoid glucosides were isolated from Cyrtomium falcatum Presl, C. Fortunei J. Sm., and its variety, var. clivicola Tagawa, by the use of chromatopile or paper partition chromatography and two new glucosides, cyrtomin and cyrtopterin, which are monoglucoside of cyrtominetin and cyrtopterinetin, respectively, were obtained besides astragalin and isoquercitrin. The flavonoids in Cyrtomium Yarnamotoi Tagawa, C. tsukusicola Tagawa, C. caryotideum Presl, and C. macrophyllum Tagawa were examined with a small amount of each material by paper partition chromatography and the results obtained are listed in Table IV.抄録全体を表示PDF形式でダウンロード (684K) -
レゾルシノール誘導体の紫外部吸収スペクトルについて金庭 延慶1956 年 76 巻 3 号 p. 253-261
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーNear-ultraviolet absorption spectra were measured of 19 compounds of resacetophenone and nitroresorcinol series in acid, neutral, and alkaline solvents. Resacetophenone series compounds were found to exhibit four absorption bands between 205 and 350 mμ, at 210-220, about 230, 270-280, and 315-330 mμ. Their spectral analysis revealed that the bands at about 230 and 315-330mμ corresponded to the two bands of o-hydroxyacetophenone, and those at 210-220 and 270-280mμ to those of p-hydroxyacetophenone. Therefore, the two bands in the longer wave length region belong to the K-band and those in the shorter region to the B-band. Relationship between the facility or difficulty of methylation of the two hydroxyls in these compounds with dimethyl sulfate and their spectra was discussed. Ultraviolet absorption maxima of the compounds which can or cannot form chelation in neutral and acid medium were compared and it was found that in both solvents, there were a difference of around 7mμ in the band at 270-280mμ and around 10mμ in the band at 315-330 between these compounds.抄録全体を表示PDF形式でダウンロード (1062K) -
アゾレゾルシノールの吸収スペクトルについて金庭 延慶1956 年 76 巻 3 号 p. 261-267
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーAbsorption spectra were measured of 12 kinds of compounds, including 4-phenylazoresorcinol, 4-(o-tolyl) azoresorcinol, 4-nitrobenzeneazoresorcinol, and the mono-and dimethyl ethers in acid, neutral, and alkaline solvents. Absorption of 4-nitrobenzeneazoresorcinol series compounds were observed only in the visible region, but the compounds of other two systems were observed up to the ultraviolet range, and the absorption maxima of the B- and K-bands were determined. The absorption maxima of these compounds were found to vary greatly according to the reaction of the solvent, shift to the longer wave length region being most marked in alkaline side. The displacement of the absorption maxima in compounds with free hydroxyl and its methylated derivatives were compared in acid and neutral medium to examine its relationship with chelation. The absorption maxima in acid solvent was found to have shifted by 10-15mμ (at 370-380mμ) due to chelation while this point remained obscure in a neutral medium. Discussions are also made on the structure of 4-nitrobenzeneazoresorcinol.抄録全体を表示PDF形式でダウンロード (902K) -
α-Phenyl-γ-tert-aminocroton酸ester類の合成杉本 典夫, 釘田 博至, 重松 暹1956 年 76 巻 3 号 p. 267-269
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーAlkyl α-phenyl-γ-tert-aminocrotonates were synthesized as having the characteristic structures of the known synthetic analgesics, 4-phenyl-4-ethoxycarbonyl-N-methylpiperidine and 1, 1-di(2′-thienyl)-3-dimethylaminobut-1-ene. Pharmacological tests revealed that (III) possessed the strongest action though it seemed to be much weaker than that of morphine.抄録全体を表示PDF形式でダウンロード (407K) -
α-(N-Methylpiperazino)又はα-Morpholino脂肪酸エステル類の合成杉本 典夫, 重松 暹, 今戸 佐太郎1956 年 76 巻 3 号 p. 270-272
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーFor the analgesic effect of analgesics, Prof. Ogyu forwarded a theory that there is a close relationship between the adrenergic and anticholinergic activities. Attempts were made to find two kinds of drugs each having such activities but not possessing any habituation tendencies in order to obtain a new analgesic without the fear of habituation. As a compound having such anticholinergic activity, fatty acid esters with N-methylpiperazino or morpholino groups in α-position were prepared.抄録全体を表示PDF形式でダウンロード (387K) -
ピラチンアミドの確認反応及び比色定量法掛見 喜一郎, 宇野 豊三, 瀬崎 仁1956 年 76 巻 3 号 p. 273-275
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーAn identification reaction for pyrazinamide using p-dimethylaminobenzaldehyde or sodium pentacyanoammineferroate was discovered. Further, coloriretric determination of pyrazinamide was carried out by the utilization of the bright red coloration exhibited by the reaction of pyrazinamide with sodium nitroprusside in sodium carbonate alkalinity. The determination is carried out after removal of pyrazinoic acid, if such is present, through anion exchange resin.抄録全体を表示PDF形式でダウンロード (451K) -
海人草有効成分ならびに関連化合物の研究 第31報中守 律夫1956 年 76 巻 3 号 p. 275-278
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーThe four isomers of kainic acid, i. e. α- (α-I), β- (β-I), α-allo- (α-allo-I), and β-allo- (β-allo-I) kainic acids, are decomposed by ozonic oxidation and form corresponding methyl ketone compounds, α-methyl (α-III), β-methyl (β-III), α-allomethyl (α-allo-III), and β-allomethyl (β-allo-III) ketone compounds. The relationship between these and the methyl ketone compounds obtained to date was clarified.抄録全体を表示PDF形式でダウンロード (578K) -
Kainic Acidおよびその異性体のオゾン酸化成績体に関する研究 (ii) Methyl Ketone体の異性化 その2中守 律夫1956 年 76 巻 3 号 p. 279-282
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーExamination of the mutual relationship between the four methyl ketone compounds reported in the preceding paper revealed that the α-methyl ketone compound (α-III) underwent facile isomerization to α-allomethyl ketone compound (α-allo-III) and that the β-methyl ketone compound (β-III) similarly underwent isomerization to β-allomethyl ketone compound (β-allo-III). It was found that (α-allo-III) can be derived to (β-allo-III) by the kainic inversion and vice versa by retrokainic inversion. These facts show that these four methyl ketone compounds are all steric isomers.抄録全体を表示PDF形式でダウンロード (621K) -
Kainic Acidおよびその異性体のオゾン酸化成績体に関する研究 (iii) N-Acetyl Methyl Ketone体中守 律夫1956 年 76 巻 3 号 p. 283-286
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーOzonolysis of N-acetyl-α-kainic acid (α-II) afforded N-acetyl-α-methyl ketone compound (α-IV) which was also derived from α-methyl ketone compound (α-III) by acetylation. On the other hand, ozonolysis of N-acetyl-α-allokainic acid (α-allo-III) gave N-acetyl-α-allomethyl ketone compound (α-allo-IV) which was also derived from α-allomethyl ketone compound (α-alto-III) by acetylation. Heating of (α-IV) with mineral acids or water resulted in concurrent isomerization and hydrolysis to form (α-allo-III), which was also obtained on the hydrolysis of (α-allo-IV). (α-IV) underwent isomerization to (α-alto-IV) when heated with glacial acetic acid.抄録全体を表示PDF形式でダウンロード (612K) -
Kainic Acidおよびその異性体のオゾン酸化成績体に関する研究 (iv) Methyl Ketone体の還元成績体中守 律夫1956 年 76 巻 3 号 p. 287-291
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーCatalytic reduction of α-methyl (α-III) and α-allomethyl (α-allo-III) ketone compounds, each in aqueous solution, respectively yielded the lactone of α-hydroxyethyl compound (α-VI) and α-allohydroxyethyl compound (α-allo-V). The same results were obtained by the catalytic reduction of (α-allo-III) in acetic acid solution. Catalytic reduction of (α-allo-III) in dilute hydrochloric acid or lactonization of (α-allo-V) in conc. sulfuric acid gave the lactone (α-allo-VI) which immediately underwent fission of the ring by neutralization to form (α-allo-V), making it impossible to isolate the lactone. It was thereby found there were a marked differences in the ease or difficulty of lactonization and stability of the lactones formed in the reduction of (α-III) and (α-allo-III).抄録全体を表示PDF形式でダウンロード (875K) -
Kainic Acidおよびその異性体のオゾン酸化成績体に関する研究(v) Methyl Ketone体の立体構造中守 律夫1956 年 76 巻 3 号 p. 291-294
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーSummarizing the experimental results reported in Parts XXXI to XXXIV of this series, the steric configuration of the four diastereoisomers of the methyl ketone compounds (III) was assumed as follows.
1) Configuration of C2-From the specific optical rotation curve based on Lutz's law, C2 in (α-III) and (α-allo-III) are in L-system and those of (β-III) and (β-allo-III) in D-system.
2) Steric configuration of carboxyl in C2 and acetic acid in C3-Since the kainic and retrokainic inversion occur between (α-allo-III) and (β-allo-III), and from other experimental results, those in (α-III) and (α-allo-III) are in cis-configuration and those in (β-III) and (β-allo-III) are in trans.
3) Configuration of acetic acid in C3 and acetyl in C4-From the facts of isomerization of (α-III) and (β-III) respectively to (α-allo-III) and (β-allo-III), and of the facile formation of a stable lactone (α-VI) by the catalytic reduction of (α-III) as against the formation of a by droxyethyl compound (α-allo-V) from (α-allo-III), the lactone (α-allo-VI) being extremely labile, those in (α-III) are in cis and those in (α-allo-III) are in trans.
Based on these assumptions, the steric structures for these four compounds were proposed as shown in Fig. 2 and in Table I.抄録全体を表示PDF形式でダウンロード (728K) -
Kainic Acidの異性化ならびに異性体に関する研究 (15) Kainic Acidおよびその諸異性体の立体構造 その3森本 浩, 中守 律夫1956 年 76 巻 3 号 p. 294-298
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーTreatment of α-kainic acid (α-I) and α-allokainic acid (α-alto-I) with conc. sulfuric acid, under the same conditions, affords a stable α-kainic acid lactone (α-VII) from (α-I) but a labile α-allokainic acid lactone (α-allo-VII) from (α-allo-I), which easily undergoes hydrolysis in aqueous solution to change to α-allohydroxy acid (α-allo-VIII). These results suggest that (α-VII) is a stable cis-lactone compound and (α-alto-VII) the labile trans-lactone compound. It follows, therefore, that the isopropenyl and acetic acid groups in kainic acid and its stereoisomers are cis in α- and β-series, and trans in α-allo- and β-allo-series. Summarizing the results herein obtained and the steric configuration of the α-carbon atom and the relationship between the carboxyl and acetic acid groups as reported in Part XXVI of this series, it seems that these steric structures are more correctly represented by those shown in Fig, 4 and Table I in the present paper, rather than those proposed in Part XXVII.抄録全体を表示PDF形式でダウンロード (845K) -
カイロン酸並びにα-アロカイニン酸の立体構造竹本 常松, 鄭 然昌, 醍醐 皓二1956 年 76 巻 3 号 p. 298-300
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーTreatment of kainic acid with hydrochloric acid or bromine water yields kainlc acid lactone or bromokainic acid lactone but the same treatment of α-allokainic acid does not afford the lactone and non-lactonized hydroxy acid alone is obtained. These experimental results also suggest the appropriateness of determining the configuration of the carboxymethyl and isopropenyl groups in kainlc acid as in cis, and those in α-allokainic acid as in trans, which can rationally explain various reactions listed in Table I.抄録全体を表示PDF形式でダウンロード (513K) -
Bis (thiazolyl-2) sulfide体の研究 その2澤 芳郎, 前田 量三1956 年 76 巻 3 号 p. 301-305
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーBy the reaction of 2-(2-mercapto-4-methyl-5-thiazolyl) ethanol (I) or ethyl 2-mercapto-4-methyl-5-thiazolylcarboxylate (VIII) and 2-(2-chloro-4-methyl-5-thiazolyl) ethanol (IV) or ethyl 2-chloro-4-methyl-5-thiazolylcarboxylate (IX), the corresponding bis (4-methyl-5-β-hydroxyethylthiazoiyl-2) sulfide (V), bis (4-methyl-5-ethoxycarbonylthiazolyl-2) sulfide (X), and 4, 4′-dimethyl-5-β-hydroxyethyl-5′-ethoxycarbonyldithiazolyl-2, 2′ sulfide (XII) were obtained. However, in the reaction of (I) and (IX), and of (IV) and (VIII), (V) and (X) were obtained as by-products besides (XII).抄録全体を表示PDF形式でダウンロード (924K) -
齋藤 徳男, 田中 千秋1956 年 76 巻 3 号 p. 305-307
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーThree kinds of oxazole-carboxylic acids were prepared. Cyclization of ethoxalyl-aminoacetophenone (I) with phosphoryl chloride in benzene afforded ethyl 5-phenyloxazole-2-carboxylate (II) as plates, m.p. 60-61°, in 70% yield. 2-Carboxylic acid (III) came as white crystalline powder, m.p. 80-82° (decomp.); hydrazide (IV), pale yellow needles, m.p. 164°. Cyclization of ethyl α-acetaminoacetoacetate (V) with phosphoryl chloride in benzene afforded ethyl 2, 5-dimethyloxazole-4-carboxylate (VI) as colorless oil, b.p11 117°, in 70% yield; hydrazide, pale yellow needles, m.p. 114-116°. Heating of ethyl α-chloroacetoacetate and benzamide, followed by hydrolysis, afforded 4-methyl-2-phenyloxazole-5-carboxylic acid as colorless needles, m.p. 237° (decomp.), yield, 2.4%.抄録全体を表示PDF形式でダウンロード (507K) -
オキサゾール-5-カルボン酸の合成について齋藤 徳男, 田中 千秋1956 年 76 巻 3 号 p. 307-309
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーBy heating ethyl α-acetoxyacetoacetate (I) and RCONH2, the corresponding 2-R-4-methyloxazole-5-carboxylic acids (III) were obtained; R=H, m. p. 238° (decomp.), R=CH3, m. p. 247° (decomp.), R=C6H5, m. p. 237° (decomp.), R=C6H5CH2, m. p. 238° (decomp.). In these reactions, 2, 4-dimethyloxazole-5-carboxylic acid (V) was invariably obtained as a by-product in each case. It was found that the presence of barium carbonate increased the amount of the carboxylic acid formed.抄録全体を表示PDF形式でダウンロード (554K) -
α, π-Dihalocamphorの発烟硫酸による異性化の機構西川 正元, 萩原 彦一1956 年 76 巻 3 号 p. 309-312
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーIt was shown in the previous paper that α-trans-π-dihalo-d-camphor underwent peculiar isomerization by fuming sulfuric acid and formed 6-trans-π-dihalo-l-camphor. From the assumption of the racemization mechanism of camphor by sulfuric acid forwarded by Asahina, it was assumed that the above reaction passed through an intermediate of 5-trans-π-dihalo-d-camphor. Therefore, 5-bromo-trans-π-chloro-d-camphor was prepared from trans-π-chlorocamphor through trans-π-chloro-d-camphoquinone, trans-π-chlorodiazo-d-camphor, and trans-π-chloro-β-pericyclocamphanone. Application of fuming sulfuric acid to the 5-bromo derivative unexpectedly revealed that it is extremely stable to this acid and no change was found to occur. The same reaction of α-bromo-6-trans-π-dichloro-l-camphor showed that this substance is also stable to fuming sulfuric acid.抄録全体を表示PDF形式でダウンロード (816K) -
芳香族硫シアンニトロ化合物の合成金子 太郎, 黒田 久寅, 飯尾 豊子1956 年 76 巻 3 号 p. 313-316
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーSince there are many antibacterial substances such as chloramphenicol and Furacin which contain a nitro group, the effect of the nitro group to animals seemed of interest. In order to test the change, if any, of physiological action by the introduction of a nitro group in aromatic thiocyano compounds, a series of aromatic thiocyanonitro compounds were prepared. Of such compounds synthesized, the present paper describes 19 new compounds besides 2-ethoxycarbonyl-4-thiocyano-3′-nitrobenzanilide, 2-carboxy-4-thiocyano-4′-nitrodiphenylurea, and 2, 3′-dinitro-4-thiocyanobenzanilide.抄録全体を表示PDF形式でダウンロード (650K) -
芳香族硫シアンニトロ化合物の対生物作用について金子 太郎, 黒田 久寅, 飯尾 豊子1956 年 76 巻 3 号 p. 316-319
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーBiological activities of aromatic thiocyano compounds, substituted with nitro group in the ring or in the side chain, were tested against Staphylococcus aureus, Escherichia coli, and Rabdias bufonis. It was thereby found that antibacterial and rabdiacidal activities were present in compounds of the general formula, R1 -SCN, in which R1 is substituted with a fat-soluble group, such as -NHCONHC6H4NO2 (p), and R2 is substituted with an electrophilic and non-dissociating group, such as -NO2 and -COOC2H5.抄録全体を表示PDF形式でダウンロード (583K) -
やまねこのめそうの一新配糖体に就いて中沖 太七郎, 森田 直賢1956 年 76 巻 3 号 p. 320-322
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーDried whole herb of Chrysosplenium japonicum Makino was extracted with methanol, the extract was treated with lead acetate, and a glycoside was obtained as yellow needles, m.p. 203° (melting once at 160°) in 0.7% yield. Its molecular formula agreed with C24H26O13⋅1 1/2H2O; [α]D23: -50.7°. Hydrolysis with 10% sulfuric acid afforded 1 mole each of a genin as yellow needles, m.p. 158-159°, C15H7O5-(OCH3)3⋅1 1/2H2O, and glucose. The glycoside was named chrysosplenin, and the genin, chrysosplenetin. Demethylation of chrysosplenetin gives quercetagetin, so that chrysosplenetin is quercetagetin trimethyl ether. Decomposition of chryso-splenetin with 3% hydrogen peroxide gives vanillic acid, and with 15% potassium hydroxide, vanillic acid and 4, 5-dimethoxyresorcinol are formed. Methylation of chrysosplenetin affords a dimethyl ether, m.p. 157-158°, and a trimethyl ether, m.p. 142-143°. The dimethyl ether agrees with the formula C15H5O3(OCH3)5⋅1 1/2H2O, and was found to be quercetagetin 3, 6, 7, 3′, 4′-pentamethyl ether by mixed fusion. It follows, therefore, that chrysosplenetin is quercetagetin 6, 7, 3′-trimethyl ether. The structure of chrysosplenin is chrysosplenetin-3 (or 5)-glucoside.抄録全体を表示PDF形式でダウンロード (474K) -
いたどり及びおおいたどりの葉の成分に就いて中沖 太七郎, 森田 直賢1956 年 76 巻 3 号 p. 323-324
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーQuercitrin was obtained in 2.5% yield from the leaves of Polygonum sachalinense Fr, Schm. (Reynoutria sachalinensis Nakai) and pale yellow needles, m.p. 203-204°, were obtained in 0.3% yield from the leaves of Polygonum Reynoutria Makino (Reynoutria japonica Houtt.). T he latter, C21H18O11⋅3H2O, was found to be quercetin-3-xyloside. This is a new substance and was named reynoutrin. Isoquercitrin or hyperin (quercetin-3-galactoside) is said to have been isolated from the leaves of Polygonum Reynoutyia, but substance corresponding to it was not obtained.抄録全体を表示PDF形式でダウンロード (363K) -
増田 克忠1956 年 76 巻 3 号 p. 325-328
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーA method was found to separatory detect cis and trans geometric isomers of urocanic acid by paper partition chromatography. By the utilization of this method, the cis isomer was isolated and purified from the sunlight irradiation product of the trans isomer, and the properties of the cis isomer were clarified. It was found by the examination of by-products formed during the synthesis of the trans isomer that a minute amount of the cis isomer is always present in it. Reversible photochemical conversion of trans to cis, and vice versa, was also examined.抄録全体を表示PDF形式でダウンロード (570K) -
5-,7-Methoxy-2-methylbenzothiazoleの合成並びにHydroxybenzothiazole類の呈色反応水野 義久, 足立 亀久夫, 橋本 忠, 斎藤 佳子1956 年 76 巻 3 号 p. 329-332
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーThe structure of the two isomers, 5- and 7-methoxy-2-methylbenzothiazole, obtained by the alkaline ferricyanide oxidation of m-thioacetanisidide, was determined by comparative examination with 5-methoxy-2-methylbenzothiazole prepared from p-anisidine. Further, four kinds of hydroxy-2-methylbenzothiazole were prepared by the hydrolysis with hydriodic acid of four kinds of methoxy-2-methyl-benzothiazoles obtained to date, and it was found that it is possible to detect the hydroxyl in α-position of the benzothiazole ring by coloration, after submitting the four hydroxylated compounds to coloration by the Driver, ferric chloride, and ammoniac copper reactions.抄録全体を表示PDF形式でダウンロード (573K) -
5-,7-Chloro-2-methylbenzothiazole及び2,5-,2,7-Dimethylbenzothiazoleの合成水野 義久, 足立 亀久夫1956 年 76 巻 3 号 p. 333-335
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーThe structures of 5- and 7-chloro-2-methylbenzothiazole, obtained by the ferricyanide oxidation of m-chlorothioacetanilide were determined by the preparation of the 5-chloro derivative from 2, 5-dichloronitrobenzene through 4-chloro-2-amino-benzenethiol. The two isomers obtained by the ferricyanide oxidation of m-thioacetotoluidide were also structurally determined by the preparation of 2, 5-dimethylbenzothiazole by a similar route as above.抄録全体を表示PDF形式でダウンロード (472K) -
Auraptene並びにRapanone岡崎 寛藏, 石川 敏1956 年 76 巻 3 号 p. 336-337
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーAntibacterial action of auraptene and rapanone, α, β-unsaturated carbonyl compounds with about 10 carbon atoms in the side chain, were tested against pathogenic fungi, gram-positive and -negative bacteria, and acid-fast bacilli. It was found that auraptene is fairly effective against these microörganisms. While rapanone was found to be extremely antagonistic to SH compounds, auraptene was found to be ineffective.抄録全体を表示PDF形式でダウンロード (240K) -
β-(4´-Methyl-5´-thiazolyl)ethylisothiuronium塩について澤 芳郎, 石田 恒子1956 年 76 巻 3 号 p. 337-338
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーBy the reaction of 4-methyl-5-β-chloroethylthiazole and thiourea, β-(4′-methyl-5′-thiazolyl) ethylisothiuronium hydrochloride was prepared and its oxidation with alkaline hydrogen peroxide yielded 4, 4′-dimethyldithiazolyl-5, 5′-diethyl disulfide dihydrochloride, m. p. 207-208°.抄録全体を表示PDF形式でダウンロード (224K) -
クロロフィル量と濾紙クロマトグラム班点の分光反射率との関係山口 一孝, 福島 清吾, 伊藤 みよ子1956 年 76 巻 3 号 p. 339-340
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーPaper chromatography of chlorophyllin was carried out to examine the relationship between the reflectancy of the spot and amount of chlorophyllin. An approximate linear relationship was found to exist between the square root of the amount of chlorophyllin and the value of 2-log R, where R is the reflectancy, as was reported previously.抄録全体を表示PDF形式でダウンロード (259K) -
斉藤 徳男, 田中 千秋, 高谷 節子1956 年 76 巻 3 号 p. 341-342
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーAs a new method of preparing dialkylaminoethyl esters of carboxylic acids, catalytic reduction of benzoylglycolonitrile, α-benzoyloxyisobutyronitrile, and diphenylacetylglycolonitrile, in the presence of dialkylamine, was carried out and the objective esters were obtained. High-pressure reduction of benzoylglycolonitrile with Raney nickel, under the same conditions, was found to cause the reduction of the ester to alcohol and benzyl alcohol was obtained.抄録全体を表示PDF形式でダウンロード (959K) -
刈米 達夫, 福井 義雄1956 年 76 巻 3 号 p. 343-344
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーThe presence of distylin (taxifolin) glucoside in the fresh leaves of Chamaecyparis obtusa var. breviramea Masters was found. Distylin has been found as its rhamnoside, astylbin, and its presence as a glucoside in the leaves of conifers is very interesting. The presence of distylin glucoside in the leaves of conifers plants other than the above may be expected.抄録全体を表示PDF形式でダウンロード (427K) -
河野 喜美彦1956 年 76 巻 3 号 p. 344-346
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーIn order to prepare phenylhydroxylamine and its derivatives possessing alkyl group in the para-position, the representative Bamberger method was followed but the objective could not be attained. Further examination of his method was made to find optimal conditions for the neutral reduction of nitrobenzene and p-nitrotoluene with zinc powder and some defective points were corrected. It was also found that, if the reduction is carried out under the same conditions, p-nitrotoluene is far more easily reduced than nitrobenzene.抄録全体を表示PDF形式でダウンロード (385K) -
みやこぐさ,やはずそう並びにほうのき,いちび葉の成分に就いて中沖 太七郎, 森田 直賢, 開 昭夫, 黒川 靖子1956 年 76 巻 3 号 p. 347-349
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーA substance corresponding to lespedin (kaempferol-3, 7-bis-rhamoside) was obtained as pale yellow needles, m. p. 181-182°, in 0.6% yield from the terrestrial portion of Lotus corniculatus L. var, japonicus Regel. Pale yellow microneedles, m. p. 236-238°, were obtained in 0.15% yield from Microlespedeza striata Makino and was found to be luteolln-7-glucoslde. Rutin was obtained in 0.2% and 0.1% respective yield from the leaves of Magnolia obovata Thunb. and of Abutilon avicennae Gaertn.抄録全体を表示PDF形式でダウンロード (582K) -
あずき,やぶつるあずき及びくずの葉の成分に就いて中沖 太七郎, 森田 直賢1956 年 76 巻 3 号 p. 349-351
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーAn identical glycoside was obtained in respective yields of 1.5%, 0.6%, and 0.35% from the leaves of Phaseolus angularis Wight, Ph. trilobatus Schreb., and Pueraria Thunbergiana Benth., as pale yellow, microneedles, m. p. 188-189° (decomp.). Its decomposition with 5% sulfuric acid afforded 1 mole of kaempferol, 2 moles of L-rhamnose, and 1 mole of D-galactose, and hydrolysis with 1% sulfuric acid gave 1 mole each of kaempferol-7-rhamnoside, L-rhamnose, and D-galactose. Decomposition with 10% barium hydroxide afforded colorless needles, m. p. 191-192°, which was found to be L-rhamnosido-D-galactose (probably robinobiose) bonded at 3-position. From the foregoing facts, this glycoside is known to be kaempferol-3-robinobio-7-rhamnoside and was found to be identical with robinin extracted from the flower of Robinia pseudacacia L. Kaempferol-3-rhamnoside is not present in the leaves of Pueraria Thunbergiana.抄録全体を表示PDF形式でダウンロード (548K) -
斎籐 清一1956 年 76 巻 3 号 p. 351-352
発行日: 1956/03/25
公開日: 2010/02/19
ジャーナル フリーHigh-pressure, catalytic reduction of saturated nitriles and cycloalkenylacetonitriles were carried out with U-Co-B catalyst, prepared from zinc powder and cobalt chloride in accordance with the preparative method for U-Ni-B. It was thereby learned that U-Co-B has approximately the same catalytic ability as that of Raney cobalt but can be prepared much easily and at cheaper cost.抄録全体を表示PDF形式でダウンロード (267K)
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