海人草有効成分ならびに関連化合物の研究 第33報

Kainic Acidおよびその異性体のオゾン酸化成績体に関する研究 (iii) N-Acetyl Methyl Ketone体

抄録

Ozonolysis of N-acetyl-α-kainic acid (α-II) afforded N-acetyl-α-methyl ketone compound (α-IV) which was also derived from α-methyl ketone compound (α-III) by acetylation. On the other hand, ozonolysis of N-acetyl-α-allokainic acid (α-allo-III) gave N-acetyl-α-allomethyl ketone compound (α-allo-IV) which was also derived from α-allomethyl ketone compound (α-alto-III) by acetylation. Heating of (α-IV) with mineral acids or water resulted in concurrent isomerization and hydrolysis to form (α-allo-III), which was also obtained on the hydrolysis of (α-allo-IV). (α-IV) underwent isomerization to (α-alto-IV) when heated with glacial acetic acid.