オキサゾールカルボン酸誘導体の合成について (第2報)

オキサゾール-5-カルボン酸の合成について

抄録

By heating ethyl α-acetoxyacetoacetate (I) and RCONH₂, the corresponding 2-R-4-methyloxazole-5-carboxylic acids (III) were obtained; R=H, m. p. 238° (decomp.), R=CH₃, m. p. 247° (decomp.), R=C₆H₅, m. p. 237° (decomp.), R=C₆H₅CH₂, m. p. 238° (decomp.). In these reactions, 2, 4-dimethyloxazole-5-carboxylic acid (V) was invariably obtained as a by-product in each case. It was found that the presence of barium carbonate increased the amount of the carboxylic acid formed.