抄録
3-Nonylpyrazole, a hydrazine condensate of decanoylacetaldehyde, the effective principle of Hauttuynia cordata T., was examined for the presence of an antibacterial activity and its correlation with the degree of surface activity was discussed. Antifungal spectrum of 3-alkylpyrazoles extends over a wide range and is effective against Trichophyton interdigitale and other non-pathogenic fungi, especially Zygosaccharomyces salsus. On the contrary, its antibacterial spectrum is extremely specific and is effective only against Staph. aureus and Bac. subtilis among the gram-positive bacteria, and Neiseria gonorrhoeae and Vibrio cholerae alone among the gram-negative bacteria. In this series, 3-nonylpyrazole, with 9 carbon atoms in the side-chain alkyl, showed the best antibacterial activity. The surface activity of 3-alkylpyrazoles is the maximum in octyl derivative with eight carbon atoms in the side-chain alkyl, decreases with the decrease of the number of carbon atoms, and its antibacterial activity also showed the same tendency.
