抄録
It has previously been reported that the effect of coumarin derivatives on the tissue respiration of albino rat brain confirmed the theory of Quastel and his school. Which enzymatic system is affected in the chief course of biological oxidation of coumarin derivatives was examined to see whether this was due to the suppressive action on the cytochrome level, as in hypnotic-anesthetics in general, as proposed by Michaelis and Quastel, or by the suppressive action on the dehydrogenase level, such as in steroids, as proposed by Gordan et al.. It was thereby concluded that the coumarin derivatives showed suppressive action against the cytochrome-cytochrome oxidase system as in hypnotic-anesthetics in general, and that their action mechanism was fundamentally different from the hypnotic action of steroids.
