チオールエステルに関する研究 (第6報)

抗黴性チオールエステルの作用様式に関する考察について その1

抄録

Antifungal thiol esters were found to have fairly strong antibacterial activity against putrefaction bacteria and pathogenic bacteria (Table I). Effect of amino acids on antifungal spectrum of thiol esters was examined by the addition of 4-aminobutyric acid, L-lysine, L-histidine, L-cysteine, L-methionine, or glutathione to phenyl acetothiolate, phenyl benzothiolate, and phenyl 3-pyridinecarbothiolate (Table II, III, and IV). As a result, marked antagonism was found to exist in thiol-amino acids like cysteine and glutathione. From the effect of addition of redox agents like ferric chloride and sodium thiosulfate, and Zn²⁺ and Cu²⁺ ions (Tables V, VI, and VII), the antifungal activity of these thiol esters was found to be markedly increased by Cu²⁺ while no influence was found from the addition of an redox agent. These facts are endorsed by the result of addition of ferric chloride and ascorbic acid on the anti-spore action of phenyl acetothiolate against Aspergillus niger (Fig. 1). These results indicate that the anti-fungal action of thiol esters is a specific inhibition of transacylation to thiol-amino acid.