錠剤の成型及び崩壊機構の研究 (第3報)
加圧成型圧力の増加による毛管容積分布の変化
1958 年 78 巻 11 号 p. 1205-1210
詳細
1958 年 78 巻 11 号 p. 1205-1210
The manner in which the void space, thought to represent flaws in compressed tablets, changes with increasing compressional force was examined by comparing the pore volume distribution of four samples from their adsorption isotherm by Shull-Wheeler's method. The peak of distribution in samples compressed at 0.76 ton/cm2 was at pore radius of 62.4Å, the pore volume at this point was 148×10-4cc/gÅ, with the distribution making a sharp upward curve, and showed Gauss distribution in the region with small pore radius and Maxwell distribution in that with large pore radius. The peak shifted to 42.4Å in samples with compression of 1.5 tons/cm2 and the pore volume decreased to 81×10-1cc/gÅ. When the compression was increased to 2.9tons/cm2, the peak of distribution became still lower, to radius of 21Å, and pore volume at that point became 60×10-4cc/gÅ, indicating that larger pores gave way to smaller pores.
