Physicochemical Studies on Isonicotinoylhydrazine Derivatives. VII

Studies on the Relationship between Equilibrium of Isonicotinoylhydrazine Derivatives in Aqueous Solution and Free Isonicotinoylhydrazine Derivatives in vivo

Abstract

As a measure of INAH liberation in vivo, convulsion dose (CD₅₀) by injection in normal mice was measured and this clarified the fact that CD₅₀ is related to equilibrium constants between free radicals in aqueous solution of INAH-hydrazone. Compounds whose equilibrium is directed towards hydrazone formation are less likely to liberate INAH in vivo.