神経節遮断剤としてのCamphor誘導体の研究 (第3報)

d-9-Aminocamphor誘導体について その2

抄録

In order to obtain ganglionic blocking agent, 9-aminocamphor was condensed with monochloroacetic acid ester to form ethyl 9-camphorylaminoacetate (I) and with acrylic acid ester to form ethyl 3-(9-camphorylamino) propionate (II). (I) and (II) were respectively methylated to form ethyl ω-[N-(9-camphoryl) methylamino] alkanecarboxylates (III and IV) which were reacted with dialkylaminoalcohol to effect ester exchange and dialkylaminoalkyl d-9-camphorylaminoalkanecarboxylates (V to XIV). These were derived to their quaternary ammonium salts. Of these compounds synthesized, (XV) to (XX), and (XXII) to (XXIV) were found to have hypotensive action.