脂質代謝に関する研究 第3報

沢潟 (Alisma plantago L.) 成分の抗脂肝作用

抄録

The extract obtained from Alisma plantago L. was examined for anti-fatty liver activity on rat fatty liver caused by low-protein diet. It was found that the more purified (1⋅1⋅1⋅1) fraction had stronger effect than the extracted component (1) and that the fraction (1⋅1⋅1⋅1) + choline corresponding to the amount of component (1) had anti-fatty liver effect equal to that of (1). Comparative examination on the standard sample of the component (1⋅1⋅1⋅1) with choline and lecithin showed that they had approximately equal anti-fatty liver activity. Component (1⋅1⋅1⋅1) and lecithin showed stronger anti-fatty liver activity when added with a small quantity of choline (in 0.01% dose which in itself showed no activity) than when used alone. The effect of component (1⋅1⋅1⋅1) on the amount of cholesterol, ratio of free and total cholesterol, phospholipid, and cholesterol lipid ratio in the serum and liver during examination of anti-fatty liver activity was examined in comparison with those of choline and lecithin, and it was found that the component (1⋅1⋅1⋅1) is a new substance, different in biological activity from choline or lecithin.