脂質代謝に関する研究 第4報
沢瀉 (Alisma plantago L.) 成分の生物学的検討
1960 年 80 巻 10 号 p. 1465-1468
詳細
1960 年 80 巻 10 号 p. 1465-1468
Some examinations were made on the biological activity of the component (1⋅1⋅1⋅1) from Alisma plantago L. and following facts were found:
1) Acute toxicity, LD50, is 780mg./kg. by intravenous injection and 1270mg./kg. by intraperitoneal injection in mice, but no death occurred on oral administration of 4000mg./kg.
2) Subacute toxicity was tested by feeding the rats on a diet added with 0.1% or 1.0% of the component (1⋅1⋅1⋅1) but there was no marked change in body weight increase, weight of various organs, or amount of liver fats after 2.5 months.
3) This component (1⋅1⋅1⋅1) of Alisma plantago L. was found to alleviate lipemia caused by fat administration but it was not possible to prove the presence of a clearing factor in the plasma.
