抄録
Several kinds of ketones (C6H5-CH2-CO-R) were submitted to the Leuckart reaction to form various amine derivatives and these amines were reacted with formaldehyde solution to prepare their N, N-dimethylated derivatives. Toxicity and analgesic action (Haffner method) of the various amine derivatives so obtained were examined. These derivatives generally had weaker action than N, N-dimethyl-1, 2-diphenylethylamine, and only p-chloro (XIII) and p-tolyl (VI) derivatives had somewhat comparable activity, although their toxicity was stronger. Optical resolution of (VI) was carried out in order to effect increase in activity. The levorotatory compound had weaker toxicity and stronger analgesic effect than the racemic compound but the activity was somewhat weaker than that of l-N, N-dimethyl-1, 2-diphenylethylamine.
