YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Pharmacognostical Studies on Umbelliferous Plants. XVIII
On the Constituents of the Roots of Angelica Keiskei KOIDZUMI
Kiyoshi HataMitsugi Kozawa
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1961 Volume 81 Issue 11 Pages 1647-1649

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Abstract
Four kinds of coumarin derivatives were isolated from Angelica Keiskei KOIDZUMI (Umbelliferae) by the process shown in Chart 1, these being psoralen (I), m. p. 161-162°, angelicin (II), m. p. 139-140°, bergapten (III), m. p. 187.5-188.5°, and xanthotoxin (IV), m. p. 146-147°. Besides these, angelic acid (V), m. p. 47-48°, and behenic acid (VI), m. p. 75-76°, were obtained as acid substances. Good results were obtained by the use of silica-gel chromatography for isolation of each of these substances but no new derivative of coumarin was obtained. Psoralen had hitherto been isolated from Leguminosae, Moraceae, and Rutaceae plants, and Hata and others had isolated it from the root of Angelica japonica A. GRAY among the Umbelliferae plants. The present result seems to suggest that psoralen might be distributed widely in the Umbelliferae plants also.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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