Abstract
Four kinds of coumarin derivatives were isolated from Angelica Keiskei KOIDZUMI (Umbelliferae) by the process shown in Chart 1, these being psoralen (I), m. p. 161-162°, angelicin (II), m. p. 139-140°, bergapten (III), m. p. 187.5-188.5°, and xanthotoxin (IV), m. p. 146-147°. Besides these, angelic acid (V), m. p. 47-48°, and behenic acid (VI), m. p. 75-76°, were obtained as acid substances. Good results were obtained by the use of silica-gel chromatography for isolation of each of these substances but no new derivative of coumarin was obtained. Psoralen had hitherto been isolated from Leguminosae, Moraceae, and Rutaceae plants, and Hata and others had isolated it from the root of Angelica japonica A. GRAY among the Umbelliferae plants. The present result seems to suggest that psoralen might be distributed widely in the Umbelliferae plants also.
