Abstract
Some derivatives of 3-aminopyrazinoic acid were prepared and their aryl derivatives were obtained by application of benzoyl, p-nitrobenzoyl, p-aminobenzoyl, p-chlorobenzoyl, furoyl, p-hydroxybenzoyl, nicotinoyl, or isonicotinoyl chloride. Various carboxamide and carboxahydrazide derivatives were also obtained from the foregoing derivatives. Antituberculosis and antifungal activity of these compounds were tested with tubercle bacilli H37Rv strain, Aspergillus niger, and Penicillium notatum. All the compounds tested showed better antitubercular action than pyrazinamide used as the control but none had better antifungal activity.
