難水溶性医薬品の水溶性誘導体の合成 (第3報)

Hydrocortisone 21-Phosphateの合成とその赤外線吸収スペクトル

抄録

Preparation of 21-phosphate of hydrocortisone was carried out by the following route. Dibenzyl chlorophosphate of hydrocortisone was esterified, debenzylation was repeated twice with sodium iodide or lithium chloride, and hydrocortisone phosphate was obtained as its cyclohexylammonium salt. From its infrared absorption spectrum, assumptions were made on the assignment for phosphorus-oxygen bonding. The compounds (VII), (VIII), (IX), and (V) were deuterated to assign the absorptions originating in OH, and the absorption at 1162cm^-1 was assigned to asymmetric stretching vibration and that at 1114cm^-1 to symmetric stretching vibration of P-O bond in (V).