1961 年 81 巻 12 号 p. 1674-1677
Steroids can be made soluble in water by derivation to the salt of a secondary phosphate. Synthesis of a secondary phosphate including a steroid was attempted on hydrocortisone with phosphorylation agent of the ROPOCl2 type but the product obtained was a bis-hydrocortisone ester. With the reagent of (RO)2POCl type, esterification using this reagent with R as phenyl gave a tertiary phosphate which easily liberated one phenyl to form the phosphate of steroid and phenyl by treatment with potassium carbonate at room temperature. With this reagent where R is benzyl, the tertiary phosphate obtained by esterification also lost one benzyl group to form a secondary phosphate by treatment with sodium iodide or lithium chloride.