1961 年 81 巻 2 号 p. 277-281
Elucidation of the reaction mechanism of quinone-activated carbon treatment was attempted in order to establish fundamental conditions for complete elimination of pyrogen by such a treatment.
Reaction of pyrogen and quinone, and experiments on adsorption and desorption of the reaction product by activated carbon were carried out with ribonucleic acid, having similar nature to pyrogen, and pyrogenic sodium alginate injection as test samples. It was thereby revealed that pyrogen (P) and quinone (Q) formed a reversible compound (PQ) like a molecular compound at the initial stage of the reaction and that this compound changed into an irreversible compound PQ like a condensation compound. This was confirmed mainly through the adsorption-desorption curve of these compounds on activated carbon and a reaction sequence illustrated in Chart 1 was presumed.