Abstract
Following the previously reported work on the condensation rate of sulfa drugs and sodium glucuronate in a solvent of acetone-water system, examinations were made in the present series of work on the condensation rate of these two substances in nonaqueous solvent system. The present method was able to give, more easily and in a better yield than the existing method, N-glucuronides of sulfa drugs and aromatic primary amines with small Kb. Dimethylformamide was used as the solvent for sulfa drugs and ethylene glycol or glycerol for sodium glucuronate. The two solutions were mixed and addition of acetic acid as the reaction catalyst gave the objective N-glucuronade. This method is thought to be of value in examination of metabolic products of sulfanilamide preparations and other aromatic primary amines and for preparation of water-soluble derivatives of these compounds.
