Abstract
N-Glucuronides of various sulfonamides are now obtained in a good yield and in high purity by the method developed by Ôgiya and Hashimoto. Concerning the fact that these N-glucuronides are soluble in water and that decrease in toxicity over the parent sulfonamide may be expected, growth inhibition of Escherichia coli by these N-glucuronides was tested in vitro. In the present series of experiments, comparative examinations were made on the growth inhibition of the N-glucuronides of sulfapyridine, sulfathiazole, sulfanilamide, and sulfadiazine in the same concentration, using each sulfa drug alone or an equimolar mixture of the sulfonamide and sodium glucuronate. It was thereby found that growth-inhibitory action is markedly weak but this inhibitive action increased according to the degree of liberation of the sulfonamide by decomposition under suitable conditions of pH and sterilization of the culture solution. This point was clarified by comparison of the decomposition rate of N-glucuronide.
