医薬品の吸収と排泄に関する研究 (第14報)
肝切片によるクロラムフェニコールの不活性化の抑制とその作用持続化
1962 年 82 巻 11 号 p. 1471-1475
詳細
1962 年 82 巻 11 号 p. 1471-1475
Chloramphenicol undergoes marked biotransformation to become inactivated and in order to inhibit this inactivation, prolongation of its action was attempted by the following method. A method for measuring the rate of inactivation was devised by examination of various conditions using liver slice of a guinea pig and this rate was measured with addition of various compounds. Comparative examination with chloramphenicol concentration at 10-4M and additive concentration of 10-3 to 10-5M showed that dozens of chemicals, including phenothiazine and ethanolamine derivatives, had the effect of inhibiting this inactivation. Several of these chemicals were tested with rabbits and combined use of these chemicals was found to give longer duration of a high blood level than by administration of chloramphenicol alone.
