3-Acetyl-4-hydroxycoumarinおよびDehydroacetic Acidの抗菌作用機作 (第1報)

抄録

Growth inhibitory action of 3-acetyl-4-hydroxycoumarin (AHC) and dehydroacetic acid (DHA) against lactobacillus and yeast was examined AHC inhibited the growth of these microörganisms both in the logarithmic and stationary phases of their multiplication. The antimicrobial activities of AHC and DHA became stronger at lower pH range. Taking account of pK′ values (AHC, 4.29; DHA, 5.12), it seems that the nondissociated form of AHC or DHA is more active than the dissociated form. The competitive effect of vitamins, amino acids, and metal ions to the growth inhibitory activity of AHC was also examined, but no restoration of the inhibition was observed by these substances except in the case of pyridoxamine which showed a slight recovery of the activity.