抄録
Analgesic action of aminoalkylaniline derivatives was examined and pharmacological action of some of the compounds with comparatively strong activity was compared with that of morphine. Compounds having methylphenethylamino group in the tertiary amino possessed the strongest analgesic effect, followed by those having a piperidyl group. Analgesic effect of these compounds is antagonized by Levallorphane and continued administration in mice produced greater tolerance. These compounds acted synergetical with barbital hypnotics, the fortifying action being stronger in compounds with stronger analgesic action. The compounds indicated, similar to morphine, mydriasis of pupils in mice, elevated body temperature of rats, and depressed the body temperature of mice. The compounds also suppressed intestinal transport in mice and rabbit respiration, and all these pharmacological actions tended to parallel their analgesic action.
Antipyretic action was found in 3′-hydroxypropionanilide derivatives. The compound having methylphenethylamino group in the tertiary amino had stronger local anesthetic and hypotensive effects than the others, and stronger action of depressing isolated heart of a toad and isolated intestine of a rabbit. All these compounds had antihistamine and antiacetylcholine actions.
