Protoberberine型アルカロイドの反応 (第4報)
Tetrahydroberberine N-Oxideの合成
1963 年 83 巻 2 号 p. 213-214
詳細
1963 年 83 巻 2 号 p. 213-214
In order to examine pharmacological effect of a suitable, water soluble derivative of 2, 3-methylenedioxy-9, 10-dimethoxy-5, 6, 13, 13a-tetrahydro-8H-dibenzo [a, g] quinolizine (tetrahydroberberine), N-oxide was prepared. N-Oxide gave colorless prisms (I), m. p. 188-190°(decomp.) and cubes (II), m. p. 218-219°(decomp.) and the former was transformed to the latter during crystallization. Infrared spectra of both products are identical. Both could be reduced with zinc dust and acetic acid but resisted to a reduction wih sodium sulfite, sodium thiosulfate and sodium borohydride.
