Pyrazole誘導体の合成研究 (第4報)
プロピオン酸エステル誘導体とアリルヒドラジンとの反応について
1963 年 83 巻 3 号 p. 318-322
詳細
1963 年 83 巻 3 号 p. 318-322
Reaction of ethyl 2-diethoxyrnethyl-3-ethoxypropionate (I) and ethyl 2-methoxy-methylene-3-ethoxypropionate (II) with arylhydrazines in ethanolic hydrochloric acid afforded ethyl 1-aryl-4-pyrazolecarboxylate (VIa-c), while the same reaction with ethyl 2-(ethoxymethoxymethyl)propionate (III) gave 1-aryl-4-methyl-2-pyrazolin-5-one (IX, XI, XIV). In case of reaction of I and II, from the results of isolation of corresponding amount of aniline to that of VI from the reaction mixture it seems reasonable to assume that pyrazoline derivative (V) would be resulted first which subsequently aromatized into pyrazole with arylhydrazines.
