ガスクロマトグラフィーによる医薬品製剤の研究 (第1報)
保存剤のガスクロマトグラフィー
1963 年 83 巻 7 号 p. 721-723
詳細
1963 年 83 巻 7 号 p. 721-723
Separatory detection of preservatives by gas chromatography was examined. A mixture of sorbic acid, benzoic acid, salicylic acid, dehydroacetic acid, menadione, and methyl, ethyl, butyl, and propyl p-hydroxybenzoate was separated completely into the componental compounds without any pretreatment, under the conditions of 30% DC 550 silicone on Celite 545, at 190°, with carrier gas of hydrogen. Salicylic acid tended to undergo thermal decomposition and phenol peak sometimes appeared in the product but no such decomposition occurred in other compounds.
