Cimicifuga属植物の成分研究(第1報) : オオバショウマの成分 その1

抄録

Ten kinds of substance were isolated from Cimicifuga acerina (SIEB. ET ZUCC.) C. TANAKA (Japanese name Ooba-shoma). Subst. I, colorless scales, m.p. 135∼136°, C₂₉H₅₀O·1/2H₂O. Subst. II, colorless needles, m.p. 235∼236°, Anal. Found : C, 67.58 ; H, 9.30. Subst. III, colorless needles, m.p. 220∼221°, C₃₀H₄₈O₅. Subst. IV, colorless needles, m.p. 216∼217°, C₃₀H₄₈O₅. Subst. V, colorless needles, m.p. 187∼189, Anal. Found : C, 65.13 ; H, 8.57. Subst. VI, colorless needles, m.p. 206∼208°, C₃₂H₄₈O₆. Subst. VII, colorless needles, m.p. 152∼153°, O₃₀H₄₈O₅. Subst. VIII, colorless mass, m.p. 201∼202°, C₃₂H₅₀O₆. Subst. IX, colorless needles, m.p. 198∼199°, C₃₀H₅₀O₄. Subst. X, colorless needles, m.p. 218∼219°, C₃₁H₅₀O₅. Subst. I was identified as β-sitosterol. Subst. II, III, IV, VI, IX, and X are triterpene alcohols with a cyclopropane ring. The substance IV, considered to be the major component, has two secondary hydroxyls, one tertiary hydroxyl, and two intramolecular ether linkages besides the cyclopropane ring. Subst. X is present in the second largest amount following IV, and contains two secondary hydroxyls, one methoxyl, and two intramolecular ethers. Subst. VI contains one acetyl, one hydroxyl, one five-membered ring ketone, and an isopropylidene group. Subst. VII and VIII are triterpene alcohols without the cyclopropane ring, and VIII contains one acetyl, one five-membered ring ketone, and two intramolecular ethers besides the hydroxyl. Subst. V is a glycoside having a compound similar to VIII as the aglycone and xylose as the sugar.