YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Effects of Some Counter Ions on Physico-chemical Properties and the Local Anesthetic Action of Dibucaine Base. III. : Effects on Blocking of Conduction in Frog's Sciatic Nerve Fibers and Solvent Affinity
Masaru AokiNoboru Yata
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1966 Volume 86 Issue 9 Pages 841-845

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Abstract

Effects of counter ions on the onset time, effective duration, and half-blocking concentration of dibucaine base were evaluated by the method described previously. They were also reviewed in reference to the ratio and rate of distribution between chloroform and water, the rate of permeation through the cellophane membrane, and the rate of diffusion in water were additionally pursued. A certain relationship was found between the ratio of distribution and half-blocking concentration, as was the case between the rate of distribution and onset time or effective duration.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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