Effects of Some Counter Ions on Physico-chemical Properties and the Local Anesthetic Action of Dibucaine Base. IV. : Effect on Interaction of Dibucaine Base and Bovine Serum Albumin

Abstract

Effects of counter ions on the interaction of dibucaine base and bovine serum albumin were investigated in reference to relations between anesthetic action and thermodynamic properties on protein binding. It seemed that entropy change of the interaction of dibucaine base and albumin was responsible for effective duration and half-blocking concentration of dibucaine base, determined on frog sciatic nerve fibers.