Studies on Xanthine and Related Compounds. V. : Uracil Cyclization of (Acylaminocyanoacetyl) ureas

Abstract

(Formamidocyanoacetyl)urea, (acetamidocyanoacetyl)urea, and their 3-methyl analogs were synthesized. These compounds underwent uracil cyclization by catalytic action of a base, with the exception of (formamidocyanoacetyl)urea, which was directly converted to 3-methylxanthine.