Synthesis of 5, 6-(Dihydropyrro1o[2, 1-a]isoquinolines

Abstract

Various kinds of 5, 6-dihydropyrro1o[2, 1-a]isoquinolines, listed in Table I, were obtained by the condensation of 1-methyl-3, 4-dihydroisoquinoline and its 6, 7-dimethoxy derivatives with various halogen ketones. Condensation of 1-methyl-3, 4-dihydro-β-carboline with halogen ketone afforded 2-methyl-3-ethoxycarbonyl-5, 6-dihydropyrrolo [2, 1-a] -β-carboline (IX).