粉末薬剤の滑沢化について(第6報) : 炭酸水素ナトリウムにステアリン酸マグネシウムを加えた際にみられる流動化の機構について

抄録

A study was made on the mechanism of lubrication of magnesium stearate when mixed with sodium bicarbonate. Addition of magnesium stearate to loosely packed sodium bicarbonate resulted in a decrease of the apparent specific volume, which indicated an increase of particle-to-particle mobility of sodium bicarbonate. According to the shear strength method, this increase of mobility was found to be due to a decrease in particle-to-particle cohesive force, but not to a decrease of internal friction. Furthermore, the decrease of cohesive force might also be considered due to a decrease of particle-to-particle surface interaction of sodium bicarbonate by the addition of magnesium stearate used as an anticoherent agent. The greatest lubrication effect of magnesium stearate on sodium bicarbonate was exhibited when the ratio of the surface area of sodium bicarbonate to that of magnesium stearate was between 1 to 1 and 5 to 1.