抄録
2-Benzyloxy-3, 4-dimethoxyphenethylamine (VIII) was synthesized from 2-benzyloxy-3, 4-dimethoxybenzaldehyde (VI) via ω-nitrostyrene derivative (VII) by the conventional method and condensation of VIII with p-methoxyphenacetyl chloride gave the amide (IX). The Bischler-Napieralski reaction of IX afforded the 3, 4-dihydroisoquinoline base but this was unexpectedly found to be the oxidation product (XI). Treatment of XI with methyl iodide, followed by reduction with sodium borohydride to the O-benzyl derivative (XII), and its debenzylation afforded the title compound (XIII).
