化学療法剤の研究(第2報)

抄録

1) 2-Chloro (or bromo)-4-(p-thiocyanatophenylazo) phenol (I or II), 2-chloro-4-(3-chloro-4-thiocyanatophenylazo) phenol (III), 2, 6-dichloro-4-(p-thiocyanatophenylazo)-phenol (IV), and 4-chloro-4'-iodo-(V) and 4-bromo-4'-chloro-2-amino-5-thiocyanatodiphenyl ether (VI) were derived to their corresponding acetyl compounds (VII to XII) by the application of acetic anhydride. The nitro compound (XIII), obtained by the application of 2-chloro-5-fluoronitrobenzene to the potassium salt of p-fluorophenol, and 2, 2'-dinitro-4, 4'-dichlorodiphenylether were reduced with stannous chloride and hydrochloric acid to the respective amino compounds (XV and XVI), and further thiocyanated with ammonium thiocyanate and bromine to thiocyanato compounds (XVII and XVIII). 2) 1-Aminonaphthalene, 5-aminoisoquinoline, and 3-aminoquinoline were derived to their thiocyanato compounds (XIX to XXI) by diazotization followed by the Sandmeyer reaction. 4-Chloroquinoline 1-oxide, 4-chloroquinazoline, and 2-chloroquinoxaline were derived to their thiocyanato compounds (XXII to XXV) by the application of potassium thiocyanate in acetic acid. 3) Antibacterial activity of all the foregoing thiocyanato compounds was tested.