Abstract
Condensation products of monomethylpyridazine 1-oxides and various substituted benzaldehydes were prepared and their anti-cancer activity was examined using Ehrlich carcinoma cells. 4-(p-Nitrostyryl) pyridazine 1-oxide (IVa), 5-(m-nitrostyryl) pyridazine 1-oxide (Vb), 5-(p-methoxystyryl) pyridazine 1-oxide (Vc), 5-(3', 4'-dimethoxystyryl) pyridazine 1-oxide (Vd), 6-(m-nitrostyryl) pyridazine 1-oxide (VIb) and 6-(p-methoxy-styryl) pyridazine 1-oxide (VIc) were found to have some anti-cancer effect against solid tumor, but none of the synthesized compounds showed a better effect than 6-mer-captopurine.
