Effects on the cardiovascular system of new 17 derivatives of benzodioxane were studied in anesthetized dogs. 8-[(1, 4-Benzodioxane-2-yl) methyl]-3-oxo-1-thia-4, 8-diazaspiro [4, 5] decane (I), 4-methyl (XI) and 4-tolyl (XIII) substituted derivatives on I have a potent increasing activity in the femoral blood flow. These compounds showed less active in the coronary blood flow, systemic blood pressure, heart rate and respiration. I was found the most desirable compound as a peripheral vasodilator with low toxicity amoug these derivatives.
