YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Ionic Diffusion and Membrane Permeability across Bovine Lens Capsule in Aqueous Aspartate Solutions
MASAYUKI NAKAGAKIMASAO KOBAYASHI
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1972 Volume 92 Issue 10 Pages 1212-1217

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Abstract
Aqueous electrolytic solution of a mixture of potassium hydrogen aspartate (KHAsp) and magnesium hydrogen aspartate [Mg(HAsp)2] was examined for the dispersion behavior of each ion and penetration through the vitreous capsule of bovine eye. Dispersion coefficient of K+ increased with increasing fraction of Mg2+ in the solution, indicating that Mg ion accelerated the dispersion of K ion, while dispersion coefficient of Mg2+ decreased with increasing fraction of K+, indicating that K ion retarded the dispersion of Mg ion. This tendency was also observed in a mixed solution of KCl and MgCl2 examined for the sake of comparison. Examination of the beavior of the solution with vitreous capsule indicated that the parameter f that expresses the interaction between the membrane and ion was greater in KHAsp-Mg(HAsp)2-H2O system than in KCl-MgCl2-H2O system, and there was a difference between K and Mg ions. It was found that the value of fMG of Mg ion increased in the presence of KHAsp.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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