A Synthesis of 10, 11-Dihydro-2, 3, 7, 8-tetramethoxy-10, 5-(N-methyliminomethano)-5H, 12H-dibenzo[a, d]cyclooctene (Homoisopavine) : Studies on the Syntheses of Heterocyclic Compounds. CDLVI (Organic)
Author's Organization:Pharmaceutical Institute, Tohoku University Pharmaceutical Institute, Tohoku University Pharmaceutical Institute, Tohoku University
Treatment of N-(2, 2-diethoxyethyl)-N-methyl-1, 3-bis(3, 4-dimethoxyphenyl)propylamine (X) with 6N hydrochloric acid at 20-25° resulted in the formation of an eight-membered ring to give homoisopavine (XI) in a good yield.