医薬品の消化管吸収におよぼすテトラサイクリン類の影響(第2報) : スルフォンアミド類の消化管吸収におよぼすテトラサイクリン類の影響について

抄録

The effect of tetracycline on the intestinal absorption of other co-existing drugs was investigated by the recirculation and the loop methods in the rat. It was found that, at pH 8.0, the absorption of sulfaguanidine, a poorly absorbable drug having no interaction with tetracycline, increased to a considerable extent in the presence of tetracycline. At pH 6.0, however, any noticeable change was not recognized. As regards sulfamine, known as a moderately absorbable drug, similar effect was not observed at pH 8.0 and 6.0. The absorption enhancement effect of demethylchlortetracycline, methyleneoxytetracycline, and oxytetracycline was also examined by similar methods. It was found that, at pH 6.0 and 8.0, these drugs except oxytetracycline exerted enhancing effect on the absorption of poorly absorbable drugs.