Studies on Aromatic Basic Ethers with Antispasmodic Activity. VII. Syntheses and Anticholinergic Activities of Homologous Phenyl 1-Phenyl-3-piperidinopropyl Ethers

Abstract

Homologous phenyl 1-phenyl-3-piperidinopropyl ethers, phenyl 1-phenyl-2-piperidinoethyl ethers, phenyl 1-phenyl-4-piperidinobutyl others, and their related compounds were synthesized and their anticholinergic activities were examined. It was thereby found that phenyl 1-phenyl-3-piperidinopropyl ethers having three methylene groups between the nitrogen atom and the oxygen atom in the molecule showed the most potent anticholinergic activities.