Examinations were made on the reaction of 2, 2-bis(methylthio)-1-nitroethylene with active methylenes (acetophenone derivatives, methyl cyanoacetate, dimedone, hydroxindole, rhodanine, 1, 1-dioxo-2, 3-dihydrobenzo[b]thiophen-3(2H)-one) and with indole derivatives as an intramolecular enamine. It was thereby found that the use of tetrahydrofuran as a solvent and sodium hydride as a base produced substitution reaction of the two methylthio groups while the use of dimethyl sulfoxide as a solvent and sodium hydroxide as a base resulted in the reaction of only one methylthio group. The reaction of compounds obtained by the above reaction with amines was also carried out.
