抄録
1) Effect of glutathione, cysteine, and thiamine on the accumulation of cadmium in the liver and kidney of rats was investigated. 2) Growth of rats was inhibited by daily intraperitonea1 administration of cadmium chloride (1 mg/kg/day as Cd) for 14 days. In combined application of glutathione, cysteine or thiamine with cadmium chloride, no apparent difference in growth curves were observed as compared to that of control animals. 3) The amount of cadmium in the kidney increased more by simultaneous administration of glutathione or cysteine with cadmium than by application of cadmium alone. By application of thiamine with cadmium, however, cadmium content in the kidney decreased marked1y. On the other hand, there was no significant difference in the amount of cadmium in the liver between cadmium administered alone and animals given glutathione, cysteine, or thiamine with cadmium. 4) Calcium content in the liver and kidney increased significantly by the administration of cacmium, as compared with the control groups, and the combined application of glutathione, cysteine, or thiamine with cadmium had little effect on the accumulation of calcium. 5) Protein-bound sulfhydryl content in the liver increased markedly by the administration of cadmium but no effect was observed in the kidney. Protein-bound su1fhydryl content in the liver decreased by the simultaneous administration of glutathione, cysteine, or thiamine with cadmium, as compared with the animals given cadmium alone.
