Studies on the Syntheses of Heterocyclic Compounds. DLXXXIV. Studies on the Syntheses of Analgetics. XL. Synthesis of 1-Substituted 3-(3-Hydroxyphenyl)-3-phenylpiperidines

Abstract

In order to obtain an effective analgetic, 1-substituted 3-(3-hydroxyphenyl)-3-phenyl-piperidine (3) was synthesized through several steps from 1-(3-methoxyphenyl)phenyl-acetonitrile (4), readily available by benzyne reaction of o-chloroanisole with phenyl-acetonitrile.