Abstract
Synthesis of 1 (or 3)-phenyl-4-oxodihydropyrimidiue (11 or 12) from the corresponding 2-thiouracil derivative (4 or 5) was investigated. These compounds (11, 12) and 3, 6-dimethyl-2-phenyl-4-oxo-3, 4-dihydropyrimidine (17) were brominated to give the 5-bromo compounds (14, 15, 19), which were allowed to react with dimethylamine. The desired 5-dimethylamino compounds (2, 3) were not obtained from 15 and 19, but 5-dimethyl-amino-6-methyl-3-phenyl-4-oxo-3, 4-dihydropyrimidine (1) was obtained from 14. Analgetic and antiinflammatory activities and acute toxicity of 1 were tested to be compared with those of 1, 3-disubstituted 5-dimethylamino-6-methyluracil (A) and aminopyrine.
