YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Studies on Quinolizine Derivatives. X. Synthesis of Cyclazine Derivatives and Their Reactions. (3)
HIROYOSHI AWAYACHIKATOSHI MASEDAYOSHINORI TOMINAGAREIKO NATSUKIYOSHIRO MATSUDAGORO KOBAYASHI
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JOURNAL FREE ACCESS

1975 Volume 95 Issue 1 Pages 13-16

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Abstract
1-Cyano-4-imino-2-methylthio-4H-pyrido [1, 2-c] pyrimidine (III) was obtained from 2-pyridineacetonitrile and dimethyl cyanamidedithiocarboxylate, and the reactivity of III was examined. The reaction of III with an amine, acetic anhydride, and methyl iodide gave the corresponding products (X, IV, and V), while III or 3-cyano-4-imino-4H-pyrido [1, 2-α] pyrimidine (IX) and dimethyl acetylenedicarboxylate afforded 1, 9-diazacycl-[3, 3, 3] azine derivative (XII) and 1, 4-diazacycl [3, 3, 3] azine derivative (XIII). The reaction of XII or XIII with an amine resulted in the formation of corresponding products (XIV, XV).
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