Abstract
(S)-(+)-8-methyl-5, 6, 7, 8-tetrahydroindane-1, 5-dione (VI) and (S)-(+)-8a-methyl-1, 2, -3, 5, 6, 7, 8, 8a-octahydro-3, 8-naphthalenedione (VII) were asymmetrically synthesized from 2-methylcyclopentane-1, 3-dione (IV) and 2-methylcyclohexane-1, 3-dione (V) using L-proline derivatives. Asymmetric synthesis of VI or VII from 2-methyl-2- (3-oxobutyl) cyclorentane-1, 3-dione (X) or 2-methyl-2- (3-oxobutyl) cyclohexane-1, 3-dione (XI) was also carried out under various reaction conditions. The reaction path of this asymmetric synthesis is discussed.
