Kessoglycol 8-Monoacetateの薬理作用

抄録

Kessoglycol and kessoglycol derivatives, such as kessoglycol 2-monoacetate, kessoglycol 8-monoacetate, kessan-2-hydroxy-8-one, kessan-2-acetoxy-8-one, and kessoglycol diacetate (active control substance) were tested for the prolongation effect on sleeping time after sodium hexobarbitate administration in mice. Kessoglycol 8-monoacetate was found to be more potent than kessoglycol diacetate in this test. In addition, some pharma-cological action of kessoglycol 8-monoacetate was examined. Its effect on spontaneous motor activity, as judged by an open-field test, and anti-electroshock convulant action were not found in mice. Hypothermic action was evidently observed by oral administration of 200mg/kg in mice. Aggressiveness response by electrostimulation was inhibited by a single administration of 100mg/kg but not by 200mg/kg of kessoglyco1 diacetate. It may be concluded from these finding, that kessoglycol 8-monoacetate has a sedative action and is more potent than kessoglycol diacetate.