抄録
The effect of metals on the reduction of 4-nitroquinoline 1-oxide (4-NQO) was examined by using ascorbic acid as a reducing agent, and Fe(II), Cu(II), Zn(II), Mo(VI), Co(II), Mn(II), Cr(III), Al(III), and W(VI) as the metals. It was found that copper and molybdenum could reduce 4-NQO to 4-hydroxyaminoquino1ine 1-oxide (4-HAQO). It was further found that molybdenum was the only metal which was specific for the reduction of 4-HAQO to 4-aminoquinoline 1-oxide (4-AQO) among the metals examined. At a higher concentration of ascorbic acid, molybdenum reduced 4-HAQO to 4-aminoquinoline(4-AQ) via 4-AQO. The reduction mechanism of 4-HAQO by molybdenum was speculated as the facile reduction of 4-HAQO by the complex formation between 4-HAQO and molybdenum blue (reduced type of molybdenum). This result would support the role of molybdenum in the enzyme groups activated by molybdenum such as xanthine oxidase and nitrate reductase.
