1977 年 97 巻 1 号 p. 24-30
Pharmacological screening with rats and mice was carried out on novel 6, 6, 8-tricyclic compounds, dibenz[b, g] [1, 5]oxazocine, dibenzo[b, g] [1, 5]thiazocine, and dimers with a 16-membered ring, especially for their central nerve action, using chlorpromazine, chlorprothixene, and imipramine as the reference compounds. Several of the compounds showed a relatively strong central nerve suppression, and a considerable number of the compounds had an anti reserpine activity. The central action of these compounds, however, was much weaker than that of the reference compounds. Some compounds were found to show a strong anti tremorine activity. Structure-activity correlation was not clear but substitution of a chlorine atom in the 3-position of the dibenz [b, g] [1, 5] oxazocine ring resulted in fortification of the central nerve suppression.