アルミナ充填層反応装置によるトリメチレンジアミンとプロピレングリコールの反応 : 実験計画法によるホモピペラジン収率最適条件の探索

抄録

The reaction of trimethylenediamine and propyleneglycol (PGL) was examined in the alumina-packed bed reactor. Main product was 2-methylhomopiperazine. Since this reaction mechanism is unknown, statistical method was used to find optimum conditions for the yield of 2-methylhomopiperazine. The first part of the investigation consisted of simplex type design. Four variables were chosen ; molar ratio of reactants (A), amount of water added (B), percentage of promoter added (C), and reaction temperature (D). Experiments in the direction of the steepest ascent based on the second-order response function showed that the optimum conditions were as follows : (A) 0.5 ml/1.0 ml (trimethylenediamine/PGL), (B) 1.087 ml/1.0 ml (H₂O/PGL), (C) 4.873% (K₂O), (D) 291.6°. Maximum yield under these conditions was 25.43%.