抄録
Drug interactions of aspirin with chlormezanone on analgesic and anti-inflammatory activities, acute toxicity, and distribution of aspirin were studied by oral administration of combined drugs to mice and rats. (1) Analgesic activity against pressure stimuli and acetic acid-induced writhing in mice was potentiated by combined use of both drugs. Combined effect of both drugs on anti-inflammatory activity against carrageenan-induced edema in rats was additive in all of combination ratios tested. In addition, chlormezanone alone was found to be ineffective for inhibition of chronic inflammations in rats. Acute toxicity in mice was antagonistically reduced by combined use of both drugs. (2) Analgesic activity and acute toxicity showed no significant difference among combinations in various weight ratios of both drugs, but anti-inflammatory activity was the most powerful in the combination of aspirin to chlormezanone of 4 : 1. (3) When combined drug (aspirin to chlormezanone=4 : 1) was administered to mice with acetic acid-induced writhing, chlermezanone increased significantly the concentration of aspirin into the tissues, including the inflamed tissue. These results suggest that the combination of aspirin with chlormezanone induces favorable effects in their pharmacological actions and potentiated analgesia is related to alterations in the distribution of aspirin by combined use of chlormezanone.
